Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

2.6K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
2.6K
Accessory Structures of the Skin: Nails01:05

Accessory Structures of the Skin: Nails

1.6K
Nails are one of the important accessory structures of the skin. They are hard, protective structures that cover the dorsal surface of the distal phalanges of fingers and toes. Nails are composed of specialized keratinized cells and serve various functions, including protection, sensation, and manual dexterity.
The main components of a nail include the following.
Nail Plate: The nail plate is the visible portion of the nail that extends beyond the fingertips or toes. It is a hard, translucent...
1.6K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

3.7K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.7K
Endocarditis II: Clinical features and Diagnostic Tests01:25

Endocarditis II: Clinical features and Diagnostic Tests

2
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
2
Cells of the Epidermis01:24

Cells of the Epidermis

3.7K
The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
3.7K
Accessory Structures of the Skin: Hair and Hair Follicles01:16

Accessory Structures of the Skin: Hair and Hair Follicles

2.1K
Hair and hair follicles are integral components of the integumentary system. Hair is a filamentous structure composed mainly of a protein called keratin. It is found on the surface of the skin throughout the body, except for areas such as the palms of the hands and soles of the feet.
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Neuroinflammation and drug-resistant epilepsy: interleukin 6 as a possible marker].

Medicina·2026
Same author

[Effect of exclusive breastfeeding on infant hospitalizations].

Medicina·2026
Same author

[Lemierre-like syndrome, an emerging diagnosis].

Medicina·2026
Same author

Hughes-Stovin syndrome (HSS) preliminary diagnostic criteria: a paradigm shift in managing pulmonary vasculitis in HSS and Behçet's disease (BD). On behalf of the HSS International Study Group (HSSISG) : Reply on Tahir Saygın Öğüt and Veli Yazısız "Comments on the proposed diagnostic criteria for Hughes-Stovin syndrome: the role of Behçet syndrome" (CLRH-D-26-01350).

Clinical rheumatology·2026
Same author

Hughes-Stovin syndrome (HSS) preliminary diagnostic criteria: a report by the HSS International Study Group (HSSISG).

Clinical rheumatology·2026
Same author

[Pneumorrhachis in the context of Hamman's syndrome due to asthmatic crisis].

Medicina·2026

Related Experiment Video

Updated: Jun 10, 2025

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:38

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

36

[Thorns in hands, think in spiny keratoderma].

Debora Pellegrini1, Daniel Padilla Salcedo1, Gabriel Noriega2

  • 1Servicio de Clínica Médica, Hospital Británico de Buenos Aires, Buenos Aires, Argentina.

Medicina
|October 14, 2024
PubMed
Summary

Spiny keratoderma, a rare skin condition, may indicate underlying cancer. A patient

Keywords:
hepatocellular carcinomaparaneoplastic syndromespiny keratoderma

More Related Videos

Author Spotlight: Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome
05:18

Author Spotlight: Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome

Published on: May 26, 2023

1.3K
Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

10.5K

Related Experiment Videos

Last Updated: Jun 10, 2025

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:38

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

36
Author Spotlight: Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome
05:18

Author Spotlight: Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome

Published on: May 26, 2023

1.3K
Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

10.5K

Area of Science:

  • Dermatology
  • Hepatology
  • Oncology

Background:

  • Spiny keratoderma is a rare dermatological condition characterized by hyperkeratotic palmoplantar lesions.
  • It can be inherited or sporadic, with sporadic cases sometimes linked to chronic diseases or neoplasms.

Observation:

  • A case study of a man in his seventh decade presenting with palmar spiny keratoderma.
  • The patient had cirrhosis due to primary sclerosing cholangitis and hepatocellular carcinoma.

Findings:

  • The patient's spiny keratoderma resolved two months post-liver transplant.
  • This remission suggests a paraneoplastic link between the skin condition and hepatocellular carcinoma.

Implications:

  • Spiny keratoderma may serve as a paraneoplastic marker for hepatocellular carcinoma.
  • This case highlights the importance of investigating underlying malignancies in patients with sporadic spiny keratoderma.
  • The report is the first of its kind from Argentina, expanding the literature on this rare manifestation.