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Updated: Jun 10, 2025
3D Cell-Printed Hypoxic Cancer-on-a-Chip for Recapitulating Pathologic Progression of Solid Cancer
Published on: January 5, 2021
Cancer-on-chip: a breakthrough organ-on-a-chip technology in cancer cell modeling
Babak Nejati1, Reza Shahhosseini2, Mobasher Hajiabbasi3
1Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract:
Cancer remains one of the leading causes of death worldwide. The unclear molecular mechanisms and complex in vivo microenvironment of tumors make it difficult to clarify the nature of cancer and develop effective treatments. Therefore, the development of new methods to effectively treat cancer is urgently needed and of great importance. Organ-on-a-chip (OoC) systems could be the breakthrough technology sought by the pharmaceutical industry to address ever-increasing research and development costs. The past decade has seen significant advances in the spatial modeling of cancer therapeutics related to OoC technology, improving physiological exposition criteria. This article aims to summarize the latest achievements and research results of cancer cell treatment simulated in a 3D microenvironment using OoC technology. To this end, we will first discuss the OoC system in detail and then demonstrate the latest findings of the cancer cell treatment study by Ooc and how this technique can potentially optimize better modeling of the tumor. The prospects of OoC systems in the treatment of cancer cells and their advantages and limitations are also among the other points discussed in this study.
Insights
Organ-on-a-chip (OoC) technology offers a novel 3D microenvironment for cancer research. This approach enhances the spatial modeling of cancer therapeutics, potentially improving treatment development.
Area of Science:
- Biomedical Engineering
- Oncology
- Drug Discovery
Background:
- Cancer is a leading global cause of death with complex molecular mechanisms.
- Developing effective cancer treatments is hindered by tumor microenvironment complexity.
- Organ-on-a-chip (OoC) technology presents a promising solution for pharmaceutical research and development costs.
Purpose of the Study:
- To summarize recent advancements in cancer cell treatment using OoC technology.
- To detail the OoC system and its application in simulating a 3D tumor microenvironment.
- To explore the potential of OoC in optimizing tumor modeling and cancer treatment strategies.
Main Methods:
- Review of the latest research on cancer cell treatment simulated in 3D microenvironments using OoC systems.
- Detailed discussion of the principles and components of OoC technology.
- Analysis of studies demonstrating OoC's capability in modeling tumor-specific conditions.
Main Results:
- OoC systems have shown significant progress in spatial modeling of cancer therapeutics.
- These systems improve physiological exposition criteria for drug testing.
- OoC technology facilitates a better understanding of tumor behavior in a controlled 3D environment.
Conclusions:
- OoC systems represent a breakthrough technology for cancer research and drug development.
- This technology offers a more physiologically relevant platform for studying cancer cell treatment.
- OoC systems hold significant promise for advancing cancer therapy, despite current limitations.
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