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Systemic Therapy for Atopic Dermatitis in Children and Adolescents: A US Expert Consensus
Lawrence F Eichenfield1,2, Mark Boguniewicz3,4, Christine T Lauren5
1Departments of Dermatology and Pediatrics, University of California San Diego, La Jolla, California, USA.
Dermatology (Basel, Switzerland)
|October 15, 2024
Summary
New guidelines offer expert recommendations for managing moderate-to-severe atopic dermatitis (AD) in children. This consensus focuses on systemic therapies, including novel biologics and small molecules, to improve treatment efficacy and safety for pediatric patients.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Atopic dermatitis (AD) is a chronic inflammatory skin condition.
- Current treatments for moderate-to-severe AD often involve systemic therapies with safety concerns.
- Novel targeted therapies offer improved efficacy and safety profiles.
Purpose of the Study:
- To develop consensus-based recommendations for systemic medication use in pediatric patients with moderate-to-severe AD.
- To provide clinicians with a standardized approach to assessing and treating pediatric AD.
- To support the integration of new therapeutic options into clinical practice.
Main Methods:
- Modified Delphi process involving US-based experts.
- Development of core recommendations for systemic treatment of pediatric AD.
- Focus on patients under 18 years of age with moderate-to-severe disease.
Main Results:
- Core recommendations for systemic therapy in pediatric moderate-to-severe AD were established.
- Guidelines address the use of conventional immunosuppressants, biologics, and small molecules.
- Emphasis on optimizing patient assessment and treatment strategies.
Conclusions:
- The consensus provides a framework for managing moderate-to-severe pediatric AD with systemic therapies.
- Recommendations aim to enhance treatment efficacy and safety by incorporating novel agents.
- Clinicians are encouraged to adopt standardized approaches and stay updated on therapeutic advancements.
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