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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

401
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Jun 10, 2025

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
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3',4'-Dihydroxyflavonol Inhibits Fibrotic Response in a Rabbit Model of Glaucoma Filtration Surgery.

Zoe Pasvanis1,2, Roy C K Kong1,2, Manisha H Shah1,2

  • 1Ophthalmology, Department of Surgery, University of Melbourne, Fitzroy, VIC 3065, Australia.

International Journal of Molecular Sciences
|October 16, 2024
PubMed
Summary
This summary is machine-generated.

3

Keywords:
antifibroticconjunctival scarringglaucoma filtration surgery

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Area of Science:

  • Ophthalmology
  • Wound Healing
  • Pharmacology

Background:

  • Glaucoma filtration surgery (GFS) success is limited by post-operative fibrosis.
  • Current treatments like Mitomycin C (MMC) have significant side effects.
  • Novel anti-scarring agents are needed to improve GFS outcomes.

Purpose of the Study:

  • To investigate the anti-scarring properties of 3',4'-dihydroxyflavonol (DiOHF).
  • To compare DiOHF's efficacy against MMC and vehicle controls in a rabbit model of GFS.

Main Methods:

  • Glaucoma filtration surgery (GFS) performed on New Zealand white rabbits.
  • Treatment groups: DiOHF eye drops, MMC intraoperative, or vehicle control.
  • Assessment of bleb morphology, collagen deposition, α-SMA, oxidative stress, angiogenesis, fibroblast activity, and inflammation at 28 days.

Main Results:

  • DiOHF treatment significantly reduced collagen accumulation, CD31, Vimentin, and CD45 expression compared to vehicle.
  • MMC-treated blebs showed increased ischemia at 7 and 28 days post-GFS.
  • DiOHF demonstrated comparable anti-scarring and anti-angiogenic effects to MMC.

Conclusions:

  • 3',4'-dihydroxyflavonol (DiOHF) effectively reduces conjunctival scarring and angiogenesis after GFS in rabbits.
  • DiOHF shows potential as a safer alternative to Mitomycin C for modulating wound healing in GFS.