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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Association between adverse childhood experiences and pregnancy morbidities: A nationwide online-based

Yuto Maeda1, Takahiro Tabuchi2, Takeo Fujiwara1

  • 1Department of Public Health, Institute of Science Tokyo, Bunkyo-ku, Tokyo, Japan.

The Journal of Obstetrics and Gynaecology Research
|October 16, 2024
PubMed

Insights

Adverse childhood experiences (ACEs) are linked to increased risks of preterm birth, preeclampsia, and gestational diabetes in Japanese women. Small-for-gestational-age was not associated with ACEs.

Area of Science:

  • Reproductive Health
  • Perinatal Epidemiology
  • Childhood Trauma Research

Background:

  • Adverse childhood experiences (ACEs) are recognized as significant determinants of long-term health outcomes.
  • The impact of ACEs on pregnancy morbidities requires further investigation, particularly in diverse populations.
  • Understanding these associations is crucial for developing targeted interventions and support systems.

Purpose of the Study:

  • To investigate the association between various ACEs and specific pregnancy morbidities in Japan.
  • To determine if there is a dose-response relationship between the number of ACEs and adverse pregnancy outcomes.
  • To identify specific pregnancy complications linked to childhood adversity.

Main Methods:

  • Utilized data from the JACSIS study, an online nationwide survey in Japan (N=5444).
  • Assessed ACEs including abuse, neglect, poverty, bullying, domestic violence, parental death, and divorce.
  • Employed multivariable logistic regression to analyze the relationship between ACEs and pregnancy morbidities (PTB, GDM, preeclampsia, SGA).

Main Results:

  • A dose-response association was observed between total ACE score and preterm birth and preeclampsia.
  • Four or more ACEs significantly increased the risk of preeclampsia (aOR: 3.06).
  • Increased risks for preterm birth (aOR: 1.42-1.61) and gestational diabetes (aOR: 1.34) were associated with specific numbers of ACEs, while small-for-gestational-age showed no association.

Conclusions:

  • Adverse childhood experiences are associated with a higher risk of preterm birth, preeclampsia, and gestational diabetes in the Japanese population.
  • The findings highlight the lasting impact of childhood adversity on maternal and infant health.
  • Further research and preventative strategies addressing ACEs are warranted to improve pregnancy outcomes.
Abstract

Keywords:
adverse childhood experiencesgestational diabetespreeclampsiapreterm birth

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