Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Fluid Mosaic Model

The Fluid Mosaic Model

The fluid mosaic model was first proposed as a visual representation of research observations. The model comprises the composition and dynamics of membranes and serves as a foundation for future membrane-related studies. The model depicts the structure of the plasma membrane with a variety of components, which include phospholipids, proteins, and carbohydrates. These integral molecules are loosely bound, defining the cell’s border and providing fluidity for optimal function.

Fluid Mosaic Model

Fluid Mosaic Model

Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich with the analogy of...

Laminar and Turbulent Flow

Laminar and Turbulent Flow

Fluid dynamics is the study of fluids in motion. Velocity vectors are often used to illustrate fluid motion in applications like meteorology. For example, wind—the fluid motion of air in the atmosphere—can be represented by vectors indicating the speed and direction of the wind at any given point on a map. Another method for representing fluid motion is a streamline. A streamline represents the path of a small volume of fluid as it flows. When the flow pattern changes with time, the streamlines...

Steady Flow of a Fluid Stream

Steady Flow of a Fluid Stream

Consider a control volume, such as a pipe with solid boundaries, through which fluid flows and changes direction due to the impulse exerted by the resulting force from the pipe walls. In steady flow, the mass of fluid entering the control volume at a given time, t, with velocity v1, is equal to the mass leaving after infinitesimal time dt, with velocity v2.
During this process, the momentum of the fluid within the control volume remains constant over the time interval dt. By applying the...

Streamlines, Streaklines, and Pathlines

Streamlines, Streaklines, and Pathlines

A streamline represents the trajectory that is always tangent to the fluid's velocity vector at any given point. The velocity of a fluid particle is always directed along the streamline, ensuring the particle continuously follows the streamline's path. Streamlines are particularly useful for visualizing the overall direction of flow in a fluid system, and they provide an instantaneous representation of the flow's velocity field. In steady flow, where conditions do not change over time,...

Steady, Laminar Flow Between Parallel Plates

Steady, Laminar Flow Between Parallel Plates

Understanding steady, laminar flow between parallel plates is essential for analyzing and designing flow in narrow rectangular channels, commonly found in various water conveyance and drainage systems. The Navier-Stokes equations govern fluid motion and are generally challenging to solve due to their nonlinearity. However, simplifications are possible in certain cases, like the steady laminar flow between parallel plates. For this scenario, we assume steady, incompressible, laminar flow.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

To the homeRNAmax: Developing an Improved Blood Self-Collection and Stabilization Platform for Remote Transcriptomic Studies.

Analytical chemistry·2026

Same author

Characterization of pre-analytical blood collection and stabilization parameters to maintain endogenous protein levels for remote blood sampling technology.

bioRxiv : the preprint server for biology·2026

Same author

The emergence and diversification of the DUX gene family across placental mammals.

Communications biology·2026

Same author

Network Formation Dynamics in Thiol-ene Crosslinked Hyaluronic Acid Hydrogels: Design Principles for In Vitro Tissue Models.

bioRxiv : the preprint server for biology·2026

Same author

Enzymatic Methods for Assembling and Modifying Hydrogel Biomaterials.

Regenerative engineering and translational medicine·2026

Same author

A robust and user-agnostic step-emulsion platform for scalable microgel fabrication.

bioRxiv : the preprint server for biology·2026

Same journal

Layered social competition coordinates reproductive hierarchy formation in ants.

bioRxiv : the preprint server for biology·2026

Same journal

Combination epigenetic-targeted therapy increases the immunogenicity of poorly immunogenic sarcomas.

bioRxiv : the preprint server for biology·2026

Same journal

Loss of LanC-like proteins delays post-injury regeneration of aging skeletal muscles.

bioRxiv : the preprint server for biology·2026

Same journal

Integrative Transfer Network: Deep Transfer Learning Across Populations and Prediction Targets.

bioRxiv : the preprint server for biology·2026

Same journal

Confidence-supported label-free metabolic imaging with FPhaS phase autofluorescence microscopy.

bioRxiv : the preprint server for biology·2026

Same journal

Sequence-encoded autoinhibition couples mRNA decapping activity to phase separation.

bioRxiv : the preprint server for biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 10, 2026

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

Suspended Tissue Open Microfluidic Patterning (STOMP).

Amanda J Haack^1,2, Lauren G Brown¹, Alex J Goldstein^3,4,5

¹Department of Chemistry, University of Washington, Seattle, WA, 98195 USA.

Biorxiv : the Preprint Server for Biology

|October 17, 2024

Summary

This summary is machine-generated.

We developed Suspended Tissue Open Microfluidic Patterning (STOMP) to create multi-region tissues for studying cell contraction at complex interfaces. This method reveals altered contractile dynamics in fibrotic-healthy and bone-ligament tissues.

More Related Videos

Microfluidic Genipin Deposition Technique for Extended Culture of Micropatterned Vascular Muscular Thin Films

Microfluidic Genipin Deposition Technique for Extended Culture of Micropatterned Vascular Muscular Thin Films

Published on: June 26, 2015

Author Spotlight: Developing a Unique Modular Microphysiological System to Mimic Human Barrier Tissue

Author Spotlight: Developing a Unique Modular Microphysiological System to Mimic Human Barrier Tissue

Published on: February 16, 2024

Related Experiment Videos

Last Updated: May 10, 2026

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

Microfluidic Genipin Deposition Technique for Extended Culture of Micropatterned Vascular Muscular Thin Films

Microfluidic Genipin Deposition Technique for Extended Culture of Micropatterned Vascular Muscular Thin Films

Published on: June 26, 2015

Author Spotlight: Developing a Unique Modular Microphysiological System to Mimic Human Barrier Tissue

Author Spotlight: Developing a Unique Modular Microphysiological System to Mimic Human Barrier Tissue

Published on: February 16, 2024

Area of Science:

Mechanobiology
Tissue Engineering
Biomaterials

Background:

Free-standing tissues are vital for studying cell contraction.
Existing methods lack the ability to model complex tissue interfaces.
There is a need for advanced tools to investigate diseased-healthy and tissue-type boundaries.

Purpose of the Study:

To develop a novel method for creating multiregional suspended tissues.
To enable the study of complex tissue interfaces, such as fibrotic-healthy and bone-ligament boundaries.
To investigate altered contractile dynamics at these interfaces.

Main Methods:

Suspended Tissue Open Microfluidic Patterning (STOMP) utilizes open microfluidics and capillary pinning.
STOMP patterns subregions within free-standing tissues.
This method allows for tissue generation in various geometries using native extracellular matrices and 4D materials.

Main Results:

STOMP successfully created multiregional suspended tissues.
Altered contractile dynamics were observed in fibrotic-healthy engineered heart tissues compared to single-region controls.
Differential contractility was noted in bone-ligament enthesis constructs versus single-tissue periodontal ligament models.

Conclusions:

STOMP is a versatile platform for generating patterned, free-standing tissues.
The method facilitates the study of complex tissue interfaces and their unique contractile behaviors.
STOMP combines suspended tissue functionality with precise patterning for dynamic, spatially controlled mechanobiology research.