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B Cell Differentiation and the Origin and Pathogenesis of Human B Cell Lymphomas

Marc A Weniger1, Marc Seifert2, Ralf Küppers3

  • 1Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Medical School, Essen, Germany.

Methods in Molecular Biology (Clifton, N.J.)
|October 18, 2024
PubMed
Summary

Errors in B cell development processes like V(D)J recombination can lead to B cell lymphomas. These cancers often involve genetic mutations and require B cell antigen receptor expression for growth.

Keywords:
B cell lymphomaB cellsChromosomal translocationClonalityGerminal centerHodgkin lymphomaImmunoglobulin genesSomatic hypermutationV gene recombination

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