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Thioamide-based fluorescent sensors for dipeptidyl peptidase 4

Hoang Anh T Phan1, Yanan Chang1, Samuel A Eaton1

  • 1Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, USA. ejpetersson@sas.upenn.edu.

Chemical Communications (Cambridge, England)
|October 23, 2024
PubMed

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Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
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