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  1. Home
  3. Clinicopathological Factors And Nomogram Construction For Lymph Node Metastasis In Locally Advanced Gastric Cancer.
  1. Home
  3. Clinicopathological Factors And Nomogram Construction For Lymph Node Metastasis In Locally Advanced Gastric Cancer.

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Clinicopathological Factors and Nomogram Construction for Lymph Node Metastasis in Locally Advanced Gastric Cancer.

Zhiyuan Yu1,2,3, Haopeng Liu4, Rui Li1,2,3

  • 1Medical School of Chinese PLA, Beijing, People's Republic of China.

Cancer Management and Research
|October 23, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

This study identifies key factors predicting lymph node metastasis in locally advanced gastric cancer (T3-4a). Findings aid in developing targeted perioperative treatments for better patient outcomes.

Keywords:
clinicopathological factorslocally advanced gastric cancerlymph node metastasisnomogram

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Gastroenterology

Background:

  • Locally advanced gastric cancer (LAGC) with subserous tissue/serous membrane infiltration (T3-4a) lacks sufficient research regarding lymph node metastasis (LNM).
  • Understanding LNM predictors is crucial for optimizing treatment strategies in these advanced stages.

Purpose of the Study:

  • To identify clinicopathological factors associated with LNM in T3 and T4a LAGC.
  • To develop predictive nomograms for LNM in T3-4a LAGC.

Main Methods:

  • Systematic literature search and screening identified 1995 T3 and 1244 T4a LAGC cases without neoadjuvant/perioperative chemotherapy.
  • Univariate and multivariate logistic regression analyses were used to identify independent risk factors for LNM.
  • Nomograms were constructed using identified independent variables.

Main Results:

  • LNM incidence was 77.1% in T3 and 83.8% in T4a LAGC.
  • Independent predictors for LNM in T3 LAGC included low serum albumin, obstruction, tumor size, histological type, lymphovascular invasion (LVI), and nerve invasion.
  • Independent predictors for LNM in T4a LAGC included low serum albumin, large tumor size, histological type, hemorrhage, neuroendocrine differentiation, and LVI.

Conclusions:

  • This study identified significant risk factors for LNM in T3-4a LAGC.
  • Developed nomograms provide valuable guidance for multidisciplinary perioperative treatment planning.