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Clinicopathological Factors and Nomogram Construction for Lymph Node Metastasis in Locally Advanced Gastric Cancer.

Zhiyuan Yu1,2,3, Haopeng Liu4, Rui Li1,2,3

  • 1Medical School of Chinese PLA, Beijing, People's Republic of China.

Cancer Management and Research
|October 23, 2024
PubMed
Summary
This summary is machine-generated.

This study identifies key factors predicting lymph node metastasis in locally advanced gastric cancer (T3-4a). Findings aid in developing targeted perioperative treatments for better patient outcomes.

Keywords:
clinicopathological factorslocally advanced gastric cancerlymph node metastasisnomogram

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Gastroenterology

Background:

  • Locally advanced gastric cancer (LAGC) with subserous tissue/serous membrane infiltration (T3-4a) lacks sufficient research regarding lymph node metastasis (LNM).
  • Understanding LNM predictors is crucial for optimizing treatment strategies in these advanced stages.

Purpose of the Study:

  • To identify clinicopathological factors associated with LNM in T3 and T4a LAGC.
  • To develop predictive nomograms for LNM in T3-4a LAGC.

Main Methods:

  • Systematic literature search and screening identified 1995 T3 and 1244 T4a LAGC cases without neoadjuvant/perioperative chemotherapy.
  • Univariate and multivariate logistic regression analyses were used to identify independent risk factors for LNM.
  • Nomograms were constructed using identified independent variables.

Main Results:

  • LNM incidence was 77.1% in T3 and 83.8% in T4a LAGC.
  • Independent predictors for LNM in T3 LAGC included low serum albumin, obstruction, tumor size, histological type, lymphovascular invasion (LVI), and nerve invasion.
  • Independent predictors for LNM in T4a LAGC included low serum albumin, large tumor size, histological type, hemorrhage, neuroendocrine differentiation, and LVI.

Conclusions:

  • This study identified significant risk factors for LNM in T3-4a LAGC.
  • Developed nomograms provide valuable guidance for multidisciplinary perioperative treatment planning.