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Related Experiment Video

Updated: Jun 9, 2025

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm

Published on: August 24, 2019

INFLAMMATORY FACTORS IN DISSECTION OF THORACIC AORTIC ANEURYSM.

A Postnov¹, T Kirichenko², Y Markina³

¹1Petrovsky National Research Center of Surgery, 119435, Moscow; 2Chazov National Medical Research Center of Cardiology, 121552, Moscow, Russia.

Georgian Medical News

|October 23, 2024

Summary

Thoracic aortic aneurysm dissection is linked to high blood pressure and inflammation. This study identified arterial hypertension and specific blood markers as key factors associated with aorta dissection in patients with thoracic aortic aneurysm.

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Last Updated: Jun 9, 2025

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm

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Novel and Innovative Hybrid Technique for Type A Aortic Dissection

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Porcine Model of Infrarenal Abdominal Aortic Aneurysm

Porcine Model of Infrarenal Abdominal Aortic Aneurysm

Published on: November 21, 2019

Area of Science:

Cardiovascular Medicine
Aortic Diseases
Vascular Biology

Background:

Thoracic aortic aneurysm (TAA) prevalence is rising, often diagnosed incidentally.
Aortic dissection is a critical complication of TAA.

Purpose of the Study:

To identify clinical, laboratory, and morphological factors associated with aortic dissection in TAA patients.
To reveal predictors of aorta wall dissection in TAA.

Main Methods:

Analysis of data from 109 TAA patients (43 with dissection).
Evaluated arterial hypertension, blood analysis, biochemistry, and Von Willebrand factor expression.
Immunomorphological assessment of vasa vasorum in the aorta.

Main Results:

Arterial hypertension significantly correlated with aortic dissection (p=0.002).
Lymphocyte (p=0.021) and segmented neutrophil (p=0.001) levels were associated with dissection.
Increased Von Willebrand factor expression and vasa vasorum prevalence were observed in dissected aortas (p=0.018).

Conclusions:

Aortic dissection in TAA is associated with hypertension.
The condition involves an inflammatory response.