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Related Concept Videos

Brain Imaging01:14

Brain Imaging

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
212

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Integrated Bioelectronic and Optogenetic Methods to Study Brain-Body Circuits.

Qiming R Zhang, Styra Xicun Wang, Ritchie Chen

    ACS Nano
    |October 23, 2024
    PubMed
    Summary
    This summary is machine-generated.

    Researchers are advancing brain-body communication understanding using new neurotechnologies. These tools explore how physiological signals influence brain states and behaviors in freely moving animals.

    Keywords:
    bioelectronicsinteroceptionneuromodulationneuroscienceoptogenetics

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    Area of Science:

    • Neuroscience
    • Bioelectronic Engineering
    • Physiology

    Background:

    • The peripheral nervous system (PNS) facilitates brain-body communication via somatic and autonomic circuits.
    • Dysregulation of these pathways is linked to various disorders, making them targets for neuromodulation.
    • Current understanding and technological capabilities for studying these circuits are rapidly evolving.

    Purpose of the Study:

    • To review recent neurobiological insights into brain-body pathways.
    • To discuss the expansion of neurotechnologies from the brain to visceral organs.
    • To highlight integrated bioelectronic and optogenetic tools for studying these circuits.

    Main Methods:

    • Focus on integrated bioelectronic devices and optogenetic tools.
    • Application of ultrapotent and red-shifted channelrhodopsins.
    • Studies in freely behaving animals to observe natural physiological signaling.

    Main Results:

    • Advancements in minimally invasive optogenetics.
    • Enhanced tools for studying complex brain-body circuits.
    • Improved understanding of how physiological signals impact brain states and behavior.

    Conclusions:

    • Integrated neurotechnologies offer powerful new ways to investigate brain-body interactions.
    • Optogenetic tools are crucial for dissecting the role of physiological signals in behavior.
    • These advancements pave the way for novel neuromodulation therapies targeting PNS dysregulation.