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Related Concept Videos

Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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Aneurysm I: Introduction01:30

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An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
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Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

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Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
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Atherosclerosis II: Clinical manifestations and prevention01:27

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

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IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
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Related Experiment Video

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Author Spotlight: Using Point-of-Care Ultrasound for Comprehensive Evaluation of the Abdominal Aorta
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Aortic Aneurysm with and without Dissection and Concomitant Atherosclerosis-Differences in a Retrospective Study.

Andrey V Suslov1,2,3, Tatiana V Kirichenko1,2, Andrey V Omelchenko4

  • 1Petrovsky National Research Center of Surgery, Moscow 119991, Russia.

Journal of Cardiovascular Development and Disease
|October 25, 2024
PubMed
Summary

Thoracic aortic aneurysm dissection occurs in younger patients and is not linked to atherosclerosis severity in men or women. This finding is crucial for understanding aneurysm development across different age groups.

Keywords:
ageatherosclerosisdissectiongender differencesthoracic aortic aneurysm

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Area of Science:

  • Cardiovascular Research
  • Aortic Disease Studies

Background:

  • Thoracic aortic aneurysm (TAA) is a dangerous condition with a high mortality rate.
  • Understanding TAA differences in men and women across age groups is essential.
  • This study investigates atherosclerotic lesions in relation to TAA dissection in different demographics.

Purpose of the Study:

  • To evaluate the relationship between atherosclerotic aortic lesions and thoracic aortic aneurysm (TAA) dissection.
  • To compare TAA characteristics in males and females across various age groups.
  • To determine if atherosclerosis stage influences TAA dissection.

Main Methods:

  • Retrospective analysis of clinical and morphological data from 43 TAA patients.
  • Patients categorized based on the presence or absence of aortic dissection.
  • Statistical analysis, including Fisher's exact test, was employed.

Main Results:

  • Patients with TAA dissection were younger (mean age 50.6 years) than those without (mean age 55.0 years).
  • TAA dissection was not associated with the stage of atherosclerotic lesions in either men or women.
  • Only 18.6% of patients exhibited severe atherosclerotic plaques (types IV and V).

Conclusions:

  • TAA dissection is not statistically associated with the stage of aortic atherosclerosis, irrespective of age or sex.
  • Severe atherosclerosis is not a prerequisite for thoracic aortic aneurysm dissection.
  • Findings suggest dissection can occur even without significant atherosclerotic changes.