Related Experiment Video
Updated: Jun 9, 2025

Preparation Of Gushukang GSK Granules for In Vivo and In Vitro Experiments
Published on: May 9, 2019
Optimization of the Homogenization Process of Ginseng Superfine Powder to Improve Its Powder Characteristics and
Mei Sun1,2, Keke Li2, Yuanpei Zhang2
1School of Biological Engineering, Dalian Polytechnic University, Dalian 116034, China.
High-pressure homogenization created a novel ginseng superfine powder, improving saponin dissolution and particle size. This method enhances health supplement bioavailability and offers sustainable botanical processing.
Area of Science:
- Food Science
- Pharmacognosy
- Materials Science
Background:
- Traditional ginseng products face challenges in powder characteristics and bioavailability.
- Evolving consumer demands necessitate innovative health supplement formulations.
Purpose of the Study:
- To prepare a novel ginseng superfine powder using high-pressure homogenization (HPH).
- To optimize HPH parameters for enhanced particle size and saponin dissolution.
- To evaluate the physical and sensory properties of the prepared ginseng powders.
Main Methods:
- Response surface methodology and Box-Behnken design were used to optimize HPH parameters (pressure, passes, concentration).
- Characterization included particle size, saponin dissolution, tap density, bulk density, flowability, water-holding capacity, appearance, and taste.
- High-pressure homogenization (HPH) was the core technique for powder superfining.
Main Results:
- Optimized HPH conditions: 15,000 psi, 3 passes, 1 kg/L concentration.
- Achieved optimized values: 55 μm particle size and 83 mg/g saponin dissolution.
- Characterization confirmed improvements in powder properties and saponin bioavailability.
Conclusions:
- The HPH process effectively produced ginseng superfine powder with enhanced characteristics.
- This method provides technical support for applying HPH to ginseng and other botanical materials.
- The approach addresses industry demands for cost-effectiveness and sustainability in supplement production.
Related Concept Videos
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Tissue Homogenization and Cell Lysis
Mechanical methods of tissue homogenization
These methods rely on applying external physical force to disrupt...
Optimizing Chromatographic Separations
Band broadening refers to spreading solute bands as they travel through the column. This broadening can impact resolution. Plate height (H) represents the length required for one theoretical plate. A lower plate height corresponds to...
Precipitation Processes
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

