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Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
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Exploring the Relationship between Telomere Length and Cognitive Changes in Post-COVID-19 Subjects
Guillermo Efrén Villar-Juárez1, Alma Delia Genis-Mendoza2,3, J Nicolas I Martínez-López4
1Escuela de Medicina, Universidad Anáhuac Querétaro, Querétaro 76246, Mexico.
Biomedicines
|October 26, 2024
Summary
SARS-CoV-2 infection impacts leukocyte telomere length (LTL), but this study found no direct link between LTL and cognitive changes in post-COVID-19 patients. Further research is needed to understand neurological impacts.
Area of Science:
- Neuroscience
- Immunology
- Genetics
Background:
- COVID-19 can cause neurocognitive symptoms.
- Leukocyte telomere length (LTL) may relate to cognitive changes post-COVID-19.
Purpose of the Study:
- To investigate the correlation between telomere length and cognitive changes in post-COVID-19 individuals.
Main Methods:
- 256 subjects with and without SARS-CoV-2 infection were analyzed.
- Cognitive function assessed using MoCA and MMSE scales.
- Leukocyte telomere length (LTL) measured via PCR; statistical analysis included ANOVA and X2 tests.
Main Results:
- Individuals with post-COVID-19 conditions showed decreased LTL compared to uninfected controls (p ≤ 0.05).
- No significant association was found between LTL and cognitive impairment in post-COVID-19 subjects.
Conclusions:
- SARS-CoV-2 infection affects LTL.
- Further research is required to monitor neurological changes in post-COVID-19 conditions.
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