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Causal Relationship Between Sjögren's Syndrome and Gut Microbiota: A Two-Sample Mendelian Randomization Study
Xinrun Wang1,2, Minghui Liu2,3, Weiping Xia1,2
1Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
Biomedicines
|October 26, 2024
Summary
This study found that certain gut bacteria, including the Eubacterium coprostanoligenes group, may protect against Sjögren
Area of Science:
- Microbiome research
- Immunology
- Genetics
Background:
- Gut microbiota composition is linked to immune diseases.
- The specific relationship between gut microbiota and Sjögren's syndrome (SS) remains unclear.
Purpose of the Study:
- To investigate the causal relationship between gut microbiota and Sjögren's syndrome (SS).
- To identify specific gut bacteria that may influence SS development.
Main Methods:
- Utilized two-sample Mendelian randomization (MR) analysis.
- Employed genome-wide association study (GWAS) summary statistics from MiBioGen, FinnGen, and EBI datasets.
- Performed sensitivity analyses to ensure result validity and employed two-step MR to explore mechanisms.
Main Results:
- Several gut bacteria, including the Eubacterium coprostanoligenes group, showed a protective association with SS.
- The Eubacterium coprostanoligenes group's protective effect was validated in an independent cohort.
- Two-step MR indicated that the Eubacterium coprostanoligenes group may protect against SS by reducing CXCL6 levels.
Conclusions:
- Identified a causal link between specific gut bacteria and SS.
- The Eubacterium coprostanoligenes group's protective role in SS, potentially mediated by CXCL6 reduction, was highlighted.
- Further research with diverse omics technologies is needed to fully understand SS pathogenesis.
