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Electrospun Fibrous Scaffolds of Polyglycerol-dodecanedioate for Engineering Neural Tissues From Mouse Embryonic Stem Cells
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Advances in Electrospun Poly(ε-caprolactone)-Based Nanofibrous Scaffolds for Tissue Engineering.

Karla N Robles1, Fatima Tuz Zahra1, Richard Mu1

  • 1TIGER Institute, Tennessee State University, Nashville, TN 37209, USA.

Polymers
|October 26, 2024
PubMed
Summary

Poly(ε-caprolactone) (PCL) scaffolds are vital for tissue engineering. Enhancing PCL-based nanofiber scaffolds through blending and structural modifications improves biocompatibility and mechanical strength for better tissue restoration.

Keywords:
biocompatibilitybiomaterialscomposite scaffoldselectrospinningnanofiberspoly(ε-caprolactone) (PCL)scaffold fabricationscaffold wettabilitytissue engineering

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Nanotechnology

Background:

  • Tissue engineering utilizes scaffolds for cell growth and tissue restoration.
  • Poly(ε-caprolactone) (PCL) is a strong, biodegradable biopolymer used in scaffolds.
  • PCL alone has limitations in cell adherence and wettability.

Purpose of the Study:

  • Review fabrication methods for electrospun PCL-based nanofibrous scaffolds.
  • Explore applications of PCL-based scaffolds in tissue engineering.
  • Highlight strategies to enhance scaffold properties.

Main Methods:

  • Electrospinning of PCL-based nanofibers (single, blended, core-shell, multi-layered).
  • Tuning nanofiber properties: diameter, composition, mechanical strength, drug-loading.
  • Employing scaffold layering, surface modification, and coating techniques.

Main Results:

  • Electrospun PCL scaffolds offer tunable properties for tissue engineering.
  • Blending PCL with other biomaterials enhances scaffold characteristics.
  • Structural modifications and surface treatments improve wettability, mechanical strength, and biocompatibility.

Conclusions:

  • Electrospun PCL-based scaffolds are promising for tissue engineering applications.
  • Fabrication techniques and modifications can optimize scaffold performance.
  • Further research can advance PCL scaffold utilization in regenerative medicine.