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[Hepatitis B markers in children with oncological diseases]
Voprosy Onkologii
|January 1, 1986
Summary
Hepatitis B virus (HBV) infection is common in infant cancer patients, particularly those with lymphoproliferative diseases. Early detection of HBV markers is crucial for managing these vulnerable patients.
Area of Science:
- Virology
- Oncology
- Pediatrics
Context:
- Hepatitis B virus (HBV) infection poses a significant health concern, especially in immunocompromised populations.
- Infant cancer patients represent a vulnerable group with potential for increased susceptibility to infections.
- Understanding the prevalence of HBV markers in this population is essential for clinical management.
Purpose:
- To determine the incidence of hepatitis B virus markers in infant cancer patients.
- To identify specific cancer types associated with a higher prevalence of hepatitis B.
- To assess the presence of active hepatitis B infection markers.
Summary:
- High-sensitivity assays detected hepatitis B surface antigen (HBsAg) in 31.7% and antibodies to HBsAg (anti-HBs) in 16.7% of 293 infant cancer patients.
- Hepatitis B markers were most prevalent in patients with lymphoproliferative diseases (60.1%).
- Hepatitis B e-antigen (HBeAg), indicating active viral replication, was found in 46.5% of HBsAg-positive patients.
Impact:
- The study reveals a high incidence of hepatitis B virus infection among infant cancer patients.
- Findings underscore the need for routine hepatitis B screening in this population.
- This information can guide vaccination strategies and treatment protocols for co-infected patients.