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Bone Remodeling and Repair

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Updated: May 12, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Programmable biomaterials for bone regeneration.

Peiran Song^1,2, Dongyang Zhou^1,2, Fuxiao Wang^1,2

¹Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.

Materials Today. Bio

|October 29, 2024

Summary

This summary is machine-generated.

Programmable biomaterials offer on-demand, controlled changes unlike traditional ones. This review explores their design, function, and applications in bone regeneration, highlighting future directions.

Keywords:

Artificial intelligence Bone regeneration Bone tissue engineering Development of biomaterials Programmable biomaterials

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Area of Science:

Biomaterials Science
Regenerative Medicine
Tissue Engineering

Background:

Traditional biomaterials exhibit irreversible, uncontrolled property changes.
Programmable biomaterials offer dynamic, on-demand adjustments in properties and functions.
This distinction is crucial for enhanced precision, safety, and control in biomedical applications.

Purpose of the Study:

To review key advances in programmable biomaterials for bone regeneration.
To examine design principles, functionalities, and applications of these advanced materials.
To classify and analyze different types of programmable biomaterials and their impact.

Main Methods:

Synthesis of recent research on programmable biomaterials.
Classification of programmable biomaterials into six distinct categories.
Analysis of structural properties and bone tissue engineering impact for each category.

Main Results:

Identified six types of programmable biomaterials: dynamic nucleic acid-based, electrically responsive, bioactive scaffolds, nanomaterials, surface-engineered implants, and stimuli-responsive release materials.
Detailed analysis of their design, properties, and specific roles in bone regeneration.
Highlighted the transition from traditional to programmable biomaterials, emphasizing improved control and safety.

Conclusions:

Programmable biomaterials represent a significant advancement over traditional materials for bone regeneration.
Challenges remain, but integration with artificial intelligence and precision medicine holds promise.
Future applications extend beyond bone regeneration to other biomedical fields.