Identification of the Novel HLA-A*03:01:01:122 Allele in a Chinese Individual Using PacBio HiFi Sequencing
Yue Han1, Yankun Li1,2, Yuqi Wang1
1Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
HLA
|October 29, 2024
Summary
A novel Human Leukocyte Antigen (HLA) allele, HLA-A*03:01:01:122, has been identified. This new HLA allele differs from a known one by a single nucleotide change within intron 3.
Area of Science:
- Immunogenetics
- Molecular Biology
- Human Leukocyte Antigen (HLA) system
Background:
- The Human Leukocyte Antigen (HLA) system is crucial for immune response.
- Polymorphisms in HLA genes contribute to diverse immune functions and disease susceptibility.
Purpose of the Study:
- To report the discovery and characterization of a new HLA-A allele.
- To detail the specific genetic variation differentiating the novel allele from a known one.
Main Methods:
- Nucleotide sequencing of HLA-A gene loci.
- Comparative analysis of DNA sequences to identify variations.
Main Results:
- A new HLA allele, designated HLA-A*03:01:01:122, was identified.
- This allele is distinguished from HLA-A*03:01:01:01 by a single nucleotide substitution in intron 3.
Conclusions:
- The identification of HLA-A*03:01:01:122 expands the known HLA allele repertoire.
- Understanding such variations is vital for high-resolution HLA typing and immunological studies.
