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RNA-seq

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Updated: Jun 9, 2025

Microarray Analysis for Saccharomyces cerevisiae

Microarray Analysis for Saccharomyces cerevisiae

Published on: April 7, 2011

ScRAPdb: an integrated pan-omics database for the Saccharomyces cerevisiae reference assembly panel.

Zepu Miao¹, Yifan Ren¹, Andrea Tarabini²

¹State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, 651 Dongfeng East Road, Guangzhou 510060, China.

Nucleic Acids Research

|October 29, 2024

Summary

This study expands the Saccharomyces cerevisiae reference assembly panel (ScRAP) to 264 strains, creating a comprehensive database (ScRAPdb) for yeast genome evolution and diversity research.

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Last Updated: Jun 9, 2025

Microarray Analysis for Saccharomyces cerevisiae

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Published on: April 7, 2011

qPCRTag Analysis - A High Throughput, Real Time PCR Assay for Sc2.0 Genotyping

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CRISPR/Cas12a Multiplex Genome Editing of Saccharomyces cerevisiae and the Creation of Yeast Pixel Art

Published on: May 28, 2019

Area of Science:

Genomics
Eukaryotic Microbiology
Population Genetics

Background:

Saccharomyces cerevisiae is a key model organism balancing complexity and tractability.
Studying natural genome evolution and functional implications in yeast requires high-quality genomic data.
Previous work established the ScRAP panel for 142 yeast strains.

Purpose of the Study:

To expand the telomere-to-telomere (T2T) S. cerevisiae reference assembly panel (ScRAP).
To create a comprehensive online database (ScRAPdb) for this expanded pangenome collection.
To integrate population-scale pan-omics data and analysis tools.

Main Methods:

Exhaustively expanded the ScRAP panel to include 264 S. cerevisiae strains and 33 outgroup strains.
Developed the ScRAPdb online database to host the pangenome collection.
Integrated pantranscriptome, panproteome, and panphenome atlases with data exploration toolkits.

Main Results:

High-quality genome assemblies and annotations for 264 diverse S. cerevisiae strains and 33 outgroup strains.
ScRAPdb now hosts an expanded pangenome collection.
Integrated pan-omics atlases and analysis tools are available for intuitive genomics analyses.

Conclusions:

ScRAPdb provides a valuable platform for the yeast community.
The database facilitates population-scale pan-omics understanding of yeast genetic and phenotypic diversity.
This resource supports research into genome evolution and functional implications in Saccharomyces cerevisiae.