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Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
[Establishment and research progress of early diagnosis system for pleural mesothelioma]
1Department of Pathology, The people's Hospital of Chuxiong Yi Autonomous Prefecture, Chuxiong 675000, China.
Abstract:
Pleural mesothelioma (PMe) was associated with asbestos exposure.The Diagnosis of PMe is difficult due to the lack of specificity of clinical signs and symptoms, although there are many tools available for early diagnosis of mesothelioma. Most PMe patients are diagnosed at an advanced stage. This article reviews advances in strategies for early diagnosis of mesothelioma, focusing on breath analysis, early diagnosis of pleural effusion cytology in patients with mesothelioma, serum biomarkers and miRNA.
Insights
Early diagnosis of pleural mesothelioma (PMe), a cancer linked to asbestos, is challenging. This review explores advancements in breath analysis, cytology, serum biomarkers, and miRNA for detecting PMe sooner.
Area of Science:
- Oncology
- Pulmonology
- Biomarker Discovery
Background:
- Pleural mesothelioma (PMe) is strongly associated with asbestos exposure.
- Diagnosis of PMe is often delayed due to non-specific symptoms, with most cases identified at advanced stages.
- Effective early diagnostic tools are crucial for improving patient outcomes.
Purpose of the Study:
- To review recent advancements in early diagnostic strategies for pleural mesothelioma.
- To highlight novel approaches including breath analysis, pleural effusion cytology, serum biomarkers, and microRNAs (miRNA).
Main Methods:
- Comprehensive literature review of emerging diagnostic technologies for PMe.
- Focus on non-invasive and minimally invasive techniques.
- Analysis of biomarkers including volatile organic compounds in breath, cytological findings, protein markers in serum, and circulating miRNAs.
Main Results:
- Breath analysis shows promise for detecting volatile organic compound patterns indicative of PMe.
- Advancements in pleural effusion cytology improve diagnostic accuracy.
- Serum biomarkers and specific miRNA profiles are emerging as potential tools for early PMe detection.
Conclusions:
- Integrating multiple diagnostic strategies, including breath analysis and novel biomarkers, can enhance early detection of pleural mesothelioma.
- Further research and clinical validation are necessary to implement these advanced diagnostic tools effectively.
- Earlier diagnosis of PMe is critical for timely intervention and improved prognosis.
