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Updated: Jun 9, 2025

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
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Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

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Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch

Jun Yang1, Tianjun Zhao2, Junping Fan3

  • 1Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.

Cell
|October 30, 2024
PubMed

Keywords:
3-sulfonated bile acidsMRGPRX4OCAbile acidscholestatic prurituscryo-EM structuredeoxycholic acidfarnesoid X receptorliver diseasesnon-alcoholic steatohepatitis

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