Colon Cancer With Bladder Invasion: A Single Center Experience

Area of Science:

• Oncology
• Surgical Oncology
• Gastrointestinal Surgery

Background:

• Colon cancer with bladder invasion presents a complex surgical challenge.
• Understanding outcomes is crucial for treatment planning and patient prognosis.

Purpose of the Study:

• To investigate the oncologic outcomes of colon cancer with bladder invasion following surgical intervention.
• To identify risk factors influencing overall survival (OS).

Main Methods:

• A retrospective analysis of 41 patients with colon cancer and bladder invasion treated between 2011 and 2022.
• Kaplan-Meier analyses and Cox proportional hazards models were used to assess risk factors for OS.

Main Results:

• Median OS varied by stage (Stage 2: 71.8 months, Stage 3: 50.8 months, Stage 4: 11.2 months).
• Patients with negative surgical margins had significantly better OS (71.8 months) compared to those with positive margins (10.5 months).
• Positive surgical margins (HR=3.64) and emergency operations (HR=4.57) were independent predictors of poorer OS.

Conclusions:

• Complete resection of colon cancer with bladder invasion can lead to favorable oncologic results.
• Balancing surgical margin status and quality of life is key in choosing between partial and radical cystectomy.
• Surgical margin involvement and emergency surgery are significant independent risk factors for overall survival.