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Movement Disorders and Its Variants.

Anne-Sophie Salabert1, Pierre Payoux2

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Nuclear medicine advances PET and SPECT imaging for movement disorders. New radiotracers improve diagnostic accuracy for neurodegenerative diseases.

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Area of Science:

  • Nuclear Medicine
  • Neuroimaging
  • Neurology

Background:

  • SPECT with DaTSCAN and PET with [18F]-FDG have been mainstays in exploring movement disorders since the 2000s.
  • Diagnostic precision in neurodegenerative diseases remains a critical challenge.

Purpose of the Study:

  • To review recent advances in PET radiotracers for diagnosing movement disorders.
  • To highlight novel imaging agents targeting various neurobiological pathways.

Main Methods:

  • Review of current and emerging PET and SPECT radiotracers.
  • Discussion of tracers targeting dopamine transporters, tau pathology, neuroinflammation, synaptic density, cholinergic function, adenosine A2A receptors, and oxidative stress.

Main Results:

  • New PET tracers like LBT 999 and tau tracers (e.g., flortaucipir) enhance diagnostic precision.
  • Emerging tracers ([18F]-ROStrace) offer insights into oxidative stress.
  • Targeting diverse pathways like neuroinflammation and synaptic density expands diagnostic capabilities.

Conclusions:

  • Advancements in PET radiotracers significantly improve diagnostic accuracy for movement disorders.
  • Novel imaging tools promise better patient management and reduced examination times.
  • The development of targeted PET tracers is revolutionizing the exploration of neurodegenerative pathologies.