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Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
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Deep Eutectic Solvents for Essential-Oil Delivery and Bacterial-Infected Wound Healing
Yaping Liu1, Di Wang1, Yaoyao Lai1
1Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 2111198, China.
Langmuir : the ACS Journal of Surfaces and Colloids
|October 31, 2024
Summary
This study developed deep eutectic solvent (DES) nanoformulations (AqEDs) to enhance essential oil (EO) properties for pharmaceutical use. The novel AqEDs improved EO solubility and demonstrated effective wound healing in vivo.
Area of Science:
- Pharmacology and Pharmaceutical Sciences
- Materials Science and Nanotechnology
- Natural Product Chemistry
Background:
- Essential oils (EOs) possess diverse pharmacological activities but face limitations in pharmaceutical applications due to poor solubility, volatility, and instability.
- Deep eutectic solvents (DESs) have shown promise in delivering biomolecules and lipophilic drugs, offering potential solutions for EO delivery challenges.
Purpose of the Study:
- To synthesize and optimize DES carriers for improving the undesirable properties of essential oils.
- To develop aqueous EO-DES nanoformulations (AqEDs) for enhanced transdermal and topical delivery.
- To evaluate the efficacy of EO-AqEDs in a preclinical wound healing model.
Main Methods:
- Optimization of DES formulations for solubilization and aqueous dispersity using *Chimonanthus nitens* Oliv. EO (COEO) as a model.
- Preparation of aqueous EO-DES nanoformulations (AqEDs) by diluting EO-DES formulations.
- Investigation of the self-assembly mechanism of EO-DES in aqueous conditions.
- In vivo evaluation of clove EO-AqEDs for promoting wound healing in a methicillin-resistant *Staphylococcus aureus* infection model.
Main Results:
- Optimized DES successfully improved the solubility and aqueous dispersity of EOs.
- The developed AqEDs formed stable nanostructures through interactions between DES and EO components.
- Clove EO-AqEDs significantly promoted *in vivo* wound healing in infected models, demonstrating good biocompatibility.
Conclusions:
- The developed AqED strategy provides a versatile platform for solubilizing EOs and overcoming their delivery limitations.
- This approach enhances the transdermal and topical application potential of essential oils for therapeutic purposes.
- The study highlights the potential of DES-based nanoformulations for improving the pharmaceutical utility of natural EOs.
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