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Biocompatible Acellular Dermal Matrix-Based Neuromorphic Device with Ultralow Voltage, Ion Channel Emulation, and
Lei Li1,2, Yihua Xu1, Qunkai Peng1
1Guangdong Provincial Key Laboratory of In-Memory Computing Chips, School of Electronic and Computer Engineering, Peking University, Shenzhen 518055, P. R. China.
ACS Nano
|October 31, 2024
Summary
This study introduces biocompatible neuromorphic devices using acellular dermal matrix (ADM). These devices offer ultralow power consumption and high stability for advanced bioelectronic applications.
Area of Science:
- Biomaterials Science
- Neuroscience
- Electronics Engineering
Background:
- Neuromorphic bioelectronics face challenges in biocompatibility, power, and stability.
- Integrating electronics with biological systems requires robust and safe materials.
Purpose of the Study:
- To develop biocompatible neuromorphic devices using acellular dermal matrix (ADM).
- To explore ADM's potential for ultralow power, high-stability bioelectronic applications.
Main Methods:
- Fabrication of neuromorphic devices from porcine-derived ADM via supercritical CO2 extraction.
- Characterization of device biocompatibility, ion channel emulation, and synaptic plasticity.
- Development of a brain-like forgetting algorithm for energy-efficient computing.
Main Results:
- ADM devices exhibit excellent biocompatibility and natural collagen scaffold preservation.
- Devices emulate biological ion channels with temperature and pH sensitivity.
- Demonstrated ultralow operating voltage (1 mV, theoretically 59 μV) and high endurance (>4x10^4 cycles).
- Achieved energy efficiency of 7 aJ/event and successful complex computing with a forgetting algorithm.
Conclusions:
- ADM-based neuromorphic devices offer a promising solution for implantable biointerfaces.
- These devices enable highly energy-efficient computing through a synergistic hardware-software approach.
- The study highlights ADM as a versatile material for advanced neuromorphic bioelectronics.
