A Multiterminal Neuromorphic Biodevice Based on Biocompatible Quaternized Chitosan by Biomimicking Synaptic...

The growing computational bottleneck of von Neumann systems underscores the urgent need for a brain-inspired, energy-efficient approach. In response, a fully biocompatible multiterminal neuromorphic biodevice was developed using an acellular dermal matrix (ADM) as a biocompatible substrate, polylactic acid (PLA) as an insulator, quaternized chitosan (QCS) as a functional layer, and Au metal as electrodes while eliminating biological rejection risks. Operating at ultralow voltages (≤5 mV), the biodevice reproduces complex neurodynamic spatial integration processes, surpassing conventional two-terminal designs and enabling the simulation of the visual nervous processor system in the context of light adaptation. Different visual receptive fields were also studied. This work provides a feasible strategy for high-performance biohybrid computing systems with minimal power consumption and further functional biomimicry.