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[Case report of a severe Mooren's ulcer]
Meriem Meddahi1, Alexandre Denoyer2, Fanny Pouillard3
1Service d'ophtalmologie, CHU de Reims, rue du Général-Koenig, 51100 Reims, France.
Annales De Pathologie
|October 31, 2024
Summary
Mooren's ulcer, an autoimmune corneal condition, presents as a peripheral ulcer. Diagnosis requires excluding systemic diseases and often involves histopathology for confirmation.
Area of Science:
- Ophthalmology
- Immunology
- Pathology
Background:
- Mooren's ulcer is a peripheral corneal ulcer linked to autoimmunity against corneal stromal antigen (calgranulin C).
- Corneal involvement is typically isolated, and differentiating it from pseudo-Mooren's ulcer (associated with systemic disease) is crucial.
- Diagnosis is often one of exclusion, necessitating a thorough etiological work-up.
Purpose of the Study:
- To report a case of Mooren's ulcer in a 78-year-old female.
- To highlight the diagnostic challenges and the role of histopathology.
- To emphasize the importance of a multidisciplinary approach in managing Mooren's ulcer.
Main Methods:
- Clinical presentation of a 78-year-old female with red eye and photophobia.
- Examination revealed a perforated perilimbic ulcer with iris prolapse.
- Diagnosis based on peripheral ulcerative keratitis, negative etiological work-up, and anatomopathological analysis.
Main Results:
- The patient presented with severe visual impairment (counting fingers) and a perforated corneal ulcer.
- Histopathological analysis of the cornea supported the diagnosis of Mooren's ulcer.
- Exclusion of systemic diseases was a key factor in the diagnosis.
Conclusions:
- Mooren's ulcer diagnosis can be challenging and requires a comprehensive approach.
- Histopathological examination can provide valuable data for diagnosis.
- A multidisciplinary team (ophthalmologists, pathologists, internists) is essential for optimal patient outcomes.
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