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Related Concept Videos

Carrier-Mediated Transport01:06

Carrier-Mediated Transport

279
Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
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Preparation and Reactions of Thiols02:33

Preparation and Reactions of Thiols

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Thiols are prepared using the hydrosulfide anion as a nucleophile in a nucleophilic substitution reaction with alkyl halides. For instance, bromobutane reacts with sodium hydrosulfide to give butanethiol.
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Facilitated Diffusion01:16

Facilitated Diffusion

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The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
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Receptor-mediated Endocytosis01:39

Receptor-mediated Endocytosis

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Overview
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Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport01:23

Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

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Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
451
Drug Absorption Mechanism: Carrier-Mediated Membrane Transport01:19

Drug Absorption Mechanism: Carrier-Mediated Membrane Transport

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Certain large, lipid-insoluble drug molecules that resemble amino acids, peptides, or glucose, require specialized carrier proteins to facilitate their diffusion across cell membranes. This transport can occur through either facilitated diffusion, which does not require energy input, or active transport, which does require energy input.
Facilitated diffusion is a passive process that utilizes human Solute Carrier (SLC) transporters. These transporters bind to the drug, undergo structural...
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Analysis of Endocytic Uptake and Retrograde Transport to the Trans-Golgi Network Using Functionalized Nanobodies in Cultured Cells
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Thiol-Mediated Uptake (TMU, TIMEUP).

Saidbakhrom Saidjalolov1, Filipe Coelho2, Jules Bouffard3

  • 1Department of Organic Chemistry, University of Geneva, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland. Saidbakhrom.Saidjalolov@unige.ch.

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PubMed
Summary
This summary is machine-generated.

This research explores dynamic covalent exchange cascades for advanced material applications. Progress is being made on the Swiss-ERC AdG TIMEUP project, focusing on translational research in this area.

Keywords:
Swiss-ERC AdGThiol-mediated uptake

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Area of Science:

  • Chemistry
  • Materials Science
  • Supramolecular Chemistry

Background:

  • Dynamic covalent chemistry offers unique opportunities for adaptive and responsive materials.
  • Translational research bridges fundamental discoveries with practical applications.

Purpose of the Study:

  • To outline the objectives and progress of the Swiss-ERC AdG project.
  • To highlight advancements in Translational Dynamic Covalent Exchange Cascades (TIMEUP).

Main Methods:

  • Review of ongoing research and development within the TIMEUP initiative.
  • Focus on the design and synthesis of dynamic covalent systems.

Main Results:

  • Summarization of key milestones achieved in the project.
  • Demonstration of progress in translational research for dynamic covalent chemistry.

Conclusions:

  • The TIMEUP project is advancing the field of dynamic covalent exchange cascades.
  • Significant progress has been made towards the project's translational objectives.