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Updated: Jun 8, 2025
Author Spotlight: Characterizing Porous Materials for Aiding the Development of Robust Metal-Organic Frameworks with Adsorption Behavior
Published on: March 8, 2024
A bifunctional luminescence sensor for biomarkers detection in serum and urine based on chemorobust Nickel(II)
Nana Lei1, Wencui Li1, Dongsheng Zhao1
1School of Chemistry and Chemical Engineering, North University of China, Taiyuan 030051, PR China.
Abstract:
The rapid detection of biomarkers in bodily fluids is vital for clinical diagnosis and regular disease monitoring. In this work, a mixed-ligand strategy was employed to successfully construct a nickel(II) metal-organic framework ([Ni(H2TPTC)(bib)(H2O)2]n, NiMOF). Outstanding thermal and chemical stabilities coupled with the favorable luminescent performances endow NiMOF significant potential as an ideal bifunctional luminescence sensor with high selectivity and sensitivity, exceptional anti-interferences and recyclable performances, as well as low LODs for detecting 3-NT biomarker through "turn-off" luminescence quenching effects and HA biomarker through "turn-on" luminescence enhancement effects. Furthermore, such developed sensor was employed to quantify 3-NT biomarker in serum samples and HA biomarker in urine samples withsatisfactory results. In addition, the possible sensing mechanisms of NiMOF towards HA and 3-NT were also proposed. This work indicates the great potentials of MOFs-based biomarkers chemosensors.
