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Diabetes Mellitus: Type 2 and Gestational01:22

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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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Updated: Jun 8, 2025

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV
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m6A epitranscriptomic modification in diabetic microvascular complications.

Li-Chan Lin1, Zhi-Yan Liu1, Jing-Jing Yang2

  • 1Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.

Trends in Pharmacological Sciences
|November 4, 2024
PubMed
Summary
This summary is machine-generated.

N6-methyladenosine (m6A) modifications regulate RNA processes and impact diabetic complications. Targeting m6A enzymes may offer new therapeutic strategies for these conditions.

Keywords:
N6-methyladenosine (m6A)demethylasediabetic microvascular complicationsepitranscriptomicsmethyltransferase

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • N6-methyladenosine (m6A) modifications are crucial epigenetic regulators of RNA metabolism.
  • These modifications influence RNA splicing, translation, and decay, impacting cellular functions.
  • Dysregulation of m6A is increasingly linked to various pathological conditions.

Purpose of the Study:

  • To review the role of m6A modifications in the pathogenesis of diabetic microvascular complications.
  • To explore the involvement of m6A-related enzymes (methyltransferases, demethylases, binding proteins) in these complications.
  • To discuss potential therapeutic strategies targeting m6A modification pathways.

Main Methods:

  • Literature review of studies investigating m6A modifications in diabetic complications.
  • Analysis of the roles of m6A-modulating enzymes in diabetic cardiomyopathy, nephropathy, retinopathy, neuropathy, and dermatosis.
  • Synthesis of current knowledge on m6A-related therapeutic targets.

Main Results:

  • m6A modification patterns are altered in diabetic microvascular complications.
  • m6A methyltransferases, demethylases, and binding proteins play significant roles in the development of these complications.
  • Specific m6A-related enzymes are implicated in diabetic cardiomyopathy, nephropathy, retinopathy, neuropathy, and dermatosis.

Conclusions:

  • m6A modification is a critical factor in the pathogenesis of diabetic microvascular complications.
  • Enzymes involved in m6A regulation represent promising therapeutic targets for managing diabetic complications.
  • Further research into m6A-targeting therapies could lead to novel treatment strategies.