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Related Concept Videos

CNS Depressants: Alcohol and Nicotine01:27

CNS Depressants: Alcohol and Nicotine

175
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
175

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Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
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Novel intervention for alcohol-associated liver disease.

Fei-Qiong Gao1, Jia-Qi Zhu2, Xu-Dong Feng3

  • 1Department of Endocrinology, The Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310003, Zhejiang Province, China.

World Journal of Gastroenterology
|November 4, 2024
PubMed
Summary

Elafibranor, a PPARα/δ agonist, shows promise in treating alcohol-associated liver disease (ALD) by reducing inflammation and fibrosis. Further research is needed to determine optimal dosage, timing, and potential side effects for this ALD therapy.

Area of Science:

  • Hepatology
  • Pharmacology
  • Gastroenterology

Background:

  • Alcohol-associated liver disease (ALD) is a significant global health issue.
  • Currently, no FDA-approved drugs effectively treat ALD.
Keywords:
Alcohol-associated liver diseaseElafibranorPathogenesisPeroxisome proliferator activated receptor α/δTherapy

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  • Targeted therapies for ALD are urgently needed.