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Multipotency and Niche of Bulge Stem Cell

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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...

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Related Experiment Video

Updated: Jun 8, 2025

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

Published on: February 28, 2013

Materials-based hair follicle engineering: Basic components and recent advances.

Yudie Lv^1,2, Weili Yang^1,2, Perumal Ramesh Kannan^1,2

¹Institute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China.

Materials Today. Bio

|November 5, 2024

Summary

Bioengineering hair follicles (HF) offers a solution for permanent hair loss by regenerating these non-renewable structures. This review covers stem cells, signaling, materials, and engineering for HF reconstruction.

Keywords:

Engineering methods Hair follicle Materials Signaling pathways Stem cells

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Last Updated: Jun 8, 2025

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

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Published on: February 7, 2016

Area of Science:

Biomedical Engineering
Dermatology
Regenerative Medicine

Background:

Hair follicles (HF) are crucial skin appendages for hair shaft production.
HFs are non-renewable, and damage can cause permanent hair loss.
Advances in biomaterials and engineering allow for HF reconstruction.

Purpose of the Study:

To review recent advances in hair follicle (HF) regulation and bioengineering.
To explore the potential of regenerated HFs for hair loss treatment and research.
To highlight the integration of key components for ex vivo HF fabrication.

Main Methods:

Review of scientific literature on hair follicle stem cells.
Analysis of signaling pathways involved in HF development.
Examination of biomaterials and engineering techniques for HF reconstruction.
Discussion of ex vivo fabrication and functional assessment of bioengineered HFs.

Main Results:

Integration of stem cells, signaling pathways, materials, and engineering methods is key for HF regeneration.
Bioengineered HFs show promise for hair loss treatment, development studies, and drug screening.
Ex vivo fabrication reduces reliance on animal transplantation for HF maturation.

Conclusions:

Regenerative approaches using bioengineered hair follicles address the limitations of natural HF resources.
Combining stem cell acquisition, signaling pathway modulation, advanced materials, and engineering methods is crucial.
Ex vivo HF rebuilding facilitates research and therapeutic applications for hair loss.