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Updated: Jun 8, 2025

An Electrochemiluminescence-Based Assay for MeCP2 Protein Variants
Published on: May 22, 2020
An electrochemiluminescence device for visualized detection of lead in practical samples
Huaanzi Hu1, Cheng Wang2, Chen Qian3
1Department of Radiotherapy, the Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University Changzhou 213003 P. R. China nxy@njmu.edu.cn.
Abstract:
Lead (Pb2+) pollution poses a significant threat to human health due to its potential accumulation through the food chain. In response to this challenge, an array of electrochemiluminescence (ECL) devices has been developed for the accurate and visualized detection of trace Pb2+, achieving an ultra-low limit of detection (LOD) of 9.8 pg L-1. The device utilizes a Pb2+-specific aptamer DNA chain, modified on gold nanoparticles (AuNPs), to create an efficient ECL probe. The integration of this ECL probe into an indium tin oxide (ITO) substrate results in a Pb2+ specific array device. With the assistance of an up-response ECL imaging system, this setup enables the accurate and visualized determination of trace Pb2+, not only in standard solution containing interference ions, but also in practical samples of Lycium ruthenicum Murr., Glycyrrhiza uralensis and lake water. This work advances the visual detection of Pb2+ using ECL-based technology, demonstrating significant potential for enhancing food safety.
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