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Multicomorbidity in Psoriasis Vulgaris: A Retrospective Analysis
Bilge Fettahlioglu Karaman1, Irem Ayse Salkin Cinki1, Varol Lutfu Aksungur1
1Cukurova University, Medical School, Department of Dermatology, Adana, Turkey.
Clinical, Cosmetic and Investigational Dermatology
|November 6, 2024
Summary
Psoriasis patients often have multiple health issues. A key cluster includes diabetes, heart disease, and cancer, suggesting a cardiometabolic link that could guide future patient management.
Area of Science:
- Dermatology
- Internal Medicine
- Epidemiology
Background:
- Psoriasis comorbidity frequencies are known, but patient clusters based on comorbidities are less studied.
- Previous research identified risk factors for psoriasis comorbidities.
- This study addresses the gap in understanding comorbidity clusters in psoriasis vulgaris.
Purpose of the Study:
- To explore risk factors associated with comorbidities in psoriasis vulgaris.
- To identify and analyze clusters of comorbidities in patients with psoriasis vulgaris.
Main Methods:
- Retrospective analysis of 452 psoriasis vulgaris patients' diagnoses from electronic medical records.
- Calculation of binary association coefficients for all comorbidity pairs.
- Hierarchical cluster analysis to identify comorbidity patterns.
Main Results:
- 40.7% of patients had multiple comorbidities; 30.5% had none.
- Comorbidity count correlated positively with age and follow-up duration.
- A significant cluster included diabetes, hepatosteatosis, hyperlipidemia, hypertension, cancer, and cardiovascular disease.
Conclusions:
- The identified comorbidity cluster suggests a strong cardiometabolic link in psoriasis patients.
- Understanding these clusters offers a novel perspective for managing psoriasis comorbidities.
- This research may inform proactive and personalized treatment strategies for psoriasis patients.
