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Evaluation of Atherosclerosis Risk in Patients with Psoriasis
Lutfullah Celik1, Anil Akray2, Yasargul Denli1
1Cukurova University, Medical School, Department of Dermatology, Adana, Turkey.
Clinical, Cosmetic and Investigational Dermatology
|March 25, 2026
Summary
Psoriasis patients show increased carotid intima-media thickness (CIMT), a marker of atherosclerosis. This risk is higher with longer disease duration and smoking, necessitating regular cardiovascular monitoring.
Area of Science:
- Cardiology
- Dermatology
- Public Health
Background:
- Psoriasis is a chronic systemic inflammatory disease extending beyond the skin.
- Atherosclerosis in psoriasis patients increases risks of severe cardiovascular events like stroke and myocardial infarction.
Purpose of the Study:
- To evaluate atherosclerosis risk in psoriasis patients.
- To measure carotid intima-media thickness (CIMT) as a marker for atherosclerosis in this population.
Main Methods:
- Included 70 plaque psoriasis patients and 50 healthy controls (ages 18-65).
- Excluded patients using systemic treatment within 6 months.
- Measured CIMT using B-mode ultrasonography, with manual measurements by a single cardiologist.
Main Results:
- Psoriasis patients exhibited significantly higher CIMT (median 0.8 mm) compared to controls (median 0.6 mm).
- Significant correlations found between CIMT and age, BMI, smoking, waist/hip circumference, HbA1c, total cholesterol, and triglycerides.
- Multivariate analysis identified cigarette use and disease duration as significant predictors of CIMT, with PASI showing a trend.
Conclusions:
- Psoriasis patients demonstrate elevated CIMT, indicating increased atherosclerosis risk.
- The increase in CIMT is exacerbated by disease duration and smoking.
- Regular atherosclerosis screening and follow-up are recommended for psoriasis patients, particularly smokers and those with long-standing disease.
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