Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

One-Compartment Model: IV Infusion01:09

One-Compartment Model: IV Infusion

Intravenous (IV) infusion is often utilized when continuous and controlled drug delivery is necessary, such as during surgery or in the treatment of chronic diseases. This method offers numerous advantages, including immediate drug action, precise control over dosage, and bypassing the first-pass metabolism.
The one-compartment model for IV infusion uses mathematical equations to describe the rate of change in drug quantity in the body. At steady-state or infusion equilibrium, the drug input...
Two-Compartment Open Model: IV Infusion01:15

Two-Compartment Open Model: IV Infusion

A two-compartment model is a vital tool in pharmacokinetics, providing an essential understanding of drug behavior, especially for those administered via zero-order intravenous infusion. This model outlines two compartments: the central compartment, where elimination occurs, and the peripheral compartment.
The model illustrates the decrease in plasma drug concentration from the central compartment with a specific equation. It shows that under steady-state conditions, the drug's input rate...
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between time to target mean arterial pressure and 90-day mortality in septic shock: a post hoc analysis of the OPTPRESS trial.

Annals of intensive care·2026
Same author

Tumor-Derived Extracellular Vesicles in Plasma for Predicting Anti-PD-1 Antibody Efficacy in Non-Small Cell Lung Cancer.

Cancer science·2026
Same author

Potential return of spontaneous circulation in Japanese out-of-hospital cardiac arrest patients with pseudo-pulseless electrical activity: a post hoc analysis of a prospective multicentric study.

Resuscitation plus·2026
Same author

Corrigendum to "Association of prehospital pupillary diameter with return of spontaneous circulation and neurological outcome after out-of-hospital cardiac arrest: A multicenter retrospective analysis" [Resusc. Plus 26 (2025) 101112].

Resuscitation plus·2026
Same author

Effect modification by chronic kidney disease on renal outcomes in septic shock patients undergoing high-MAP targeting: a secondary analysis of the OPTPRESS trial.

Journal of intensive care·2026
Same author

Mediastinal drain-induced bronchoperitoneal fistula following esophageal perforation: a case report.

Journal of surgical case reports·2026

Related Experiment Video

Updated: Jul 6, 2026

Aseptic Laboratory Techniques: Volume Transfers with Serological Pipettes and Micropipettors
11:43

Aseptic Laboratory Techniques: Volume Transfers with Serological Pipettes and Micropipettors

Published on: May 31, 2012

163.1K

A Comparison of Pumping Infusion-Induced Contamination With Different Syringe Types.

Yutaka Kawakami1,2, Takashi Tagami1,2

  • 1Author Affiliations: Department of Emergency and Critical Care Medicine, Nippon Medical School Musashikosugi Hospital, Nakahara-ku, Kawasaki, Japan.

Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society
|November 6, 2024
PubMed
Summary

Pump infusion with a syringe (PIS) can cause bacterial contamination. Syringes with plastic covers and ethanol disinfection prevented contamination, highlighting the need for aseptic techniques and alternative devices.

More Related Videos

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
09:57

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

Published on: July 13, 2019

12.9K
Subconjunctival Administration of Adeno-associated Virus Vectors in Small Animal Models
06:16

Subconjunctival Administration of Adeno-associated Virus Vectors in Small Animal Models

Published on: March 16, 2022

2.8K

Related Experiment Videos

Last Updated: Jul 6, 2026

Aseptic Laboratory Techniques: Volume Transfers with Serological Pipettes and Micropipettors
11:43

Aseptic Laboratory Techniques: Volume Transfers with Serological Pipettes and Micropipettors

Published on: May 31, 2012

163.1K
A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
09:57

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

Published on: July 13, 2019

12.9K
Subconjunctival Administration of Adeno-associated Virus Vectors in Small Animal Models
06:16

Subconjunctival Administration of Adeno-associated Virus Vectors in Small Animal Models

Published on: March 16, 2022

2.8K

Area of Science:

  • Medical Devices
  • Infectious Disease Prevention
  • Patient Safety

Background:

  • Healthcare providers utilize various syringes for therapeutic agent delivery.
  • Pump infusion with a syringe (PIS) is critical for rapid fluid/blood delivery in emergencies.
  • Bacterial infections, like catheter-related bloodstream infections, are a significant risk for critically ill patients.

Purpose of the Study:

  • To compare PIS-induced contamination across different syringe types.
  • To evaluate the effectiveness of plastic covers and ethanol disinfection in preventing contamination.
  • To assess the risk of bacterial contamination associated with PIS.

Main Methods:

  • Comparison of contamination levels among disposable plastic syringes, glass syringes, and syringes with plastic covers.
  • Evaluation of PIS-induced contamination.
  • Assessment of disinfection with ethanol.

Main Results:

  • Plastic syringes showed comparable PIS-induced contamination.
  • Glass syringes exhibited substantially higher contamination than plastic syringes.
  • Syringes with plastic covers demonstrated no contamination; ethanol disinfection completely prevented contamination.

Conclusions:

  • PIS can contribute to bacterial contamination, necessitating strict aseptic techniques, particularly with glass syringes.
  • Syringes with plastic covers offer a contamination-free solution.
  • Development of alternative rapid infusion devices is warranted to enhance patient safety.