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Octreotide-LAR in ADPKD patients with very low kidney function: a single-center real-life experience

Eleonora Riccio1, Maria Amicone2, Ivana Capuano2

  • 1Chair of Nephrology, Department of Public Health, Federico II University, Naples, Italy. Eleonora.riccio83@gmail.com.

Journal of Nephrology
|November 6, 2024
PubMed
Abstract

No abstract available in PubMed .

Keywords:
ADPKDOcteotride-LARSomatostatin analogueeGFR slope

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In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
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