Related Experiment Video
Updated: Jun 8, 2025
Transuterine Fetal Tracheal Occlusion Model in Mice
Published on: February 5, 2021
Association between Time with Open Ductus Arteriosus and Outcomes in Congenital Diaphragmatic Hernia
Srirupa Hari Gopal1, Robert Tillman2, James D Hammond Ii3
1Department of Neonatal-Perinatal Medicine, Baylor College of Medicine, Houston, Texas, USA.
Introduction:
While a patent ductus arteriosus (PDA) helps offload the right ventricle in the acute congenital diaphragmatic hernia (CDH)-associated pulmonary hypertension, its role on long-term outcomes in CDH has not been investigated. Our objective was to examine associations of the PDA with long-term clinical outcomes in CDH.
Methods:
A single-center retrospective descriptive study of 122 CDH patients dichotomized by duration with PDA, as ≤14 versus >14 postnatal days (PND) and ≤30 versus >30 PND. Fisher's exact test, Wilcoxon rank-sum test, and multiple linear and logistic regression analyses were used for analyses.
Results:
In unadjusted and adjusted for CDH severity comparisons, patients with PDA >14 PND and >30 PND had a higher risk of death, longer length of stay, mechanical ventilation duration, and need for tracheostomy, diuretics, and PH medications at discharge.
Conclusion:
A PDA beyond the newborn period is associated with adverse outcomes in infants with CDH.
