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Updated: Jun 8, 2025

Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion
Published on: November 10, 2023
Onset of ANCA-positive EGPA with bilateral pleural effusion: a case report
Alessandra Marchese1, Rocco Accogli1, Annalisa Frizzelli1
1Pneumologia, Dipartimento di Medicina e Chirurgia, Università degli studi di Parma, Parma, Italy.
Background:
Eosinophilic granulomatosis with polyangiitis (EGPA) is a multisystemic, immune-mediated disease that occurs in patients with asthma and eosinophilia. It is characterized by inflammation of small- and medium-caliber blood vessels.
Case Report:
This report presents an unusual clinical case of EGPA with positive anti-neutrophil cytoplasmic antibodies who manifested bilateral pleural effusion. The diagnosis was confirmed through laboratory assessments and bronchial biopsies. The patient was treated with methylprednisolone showing improvement in symptoms.
Conclusions:
Our case appear interesting considering the limited evidence of pleural effusion in patients with EGPA documented in the literature.
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