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Follow the CSF flow: probing multiciliated ependymal cells in brain pathology
Adam M R Groh1, Liam Hodgson2, Danilo Bzdok3
1Montreal Neurological Institute-Hospital, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
Trends in Molecular Medicine
|November 8, 2024
Abstract
None:
Multiciliated ependymal cells regulate cerebrospinal fluid (CSF) microcirculation and form a dynamic CSF-brain interface. Emerging evidence suggests that ependymal cells enter reactive states in response to pathology that are associated with ciliary and junctional protein alterations. The drivers of these alterations, likely from both acquired and inherited mechanisms, remain elusive.

