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Revisiting the GBB reaction and redefining its relevance in medicinal chemistry: A review
Pratibha Shukla1, Chandra Sourabh Azad2, Deepa Deswal1
1Centre of Excellence in Pharmaceutical Sciences (CEPS), Guru Gobind Singh Indraprastha University, New Delhi 110078, India.
Abstract:
Multicomponent reactions (MCRs) have significant relevance in the field of synthetic chemistry, and in recent times one of the MCR variants, named the Groebke-Blackburn-Bienaymé (GBB) reaction, has attracted massive attention for the synthesis of biologically important scaffolds. The present review elaborates on the chemical advancement reported for the GBB reaction with an emphasis on the role of various catalytic systems. Further, the role of the GBB reaction has been redefined as a standard protocol for the synthesis of an array of potential bioactive compounds.
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