Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ventral tegmental stimulation modulates centrally induced escape responding.

J L Moreau, P Schmitt, P Karli

    Physiology & Behavior
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Dobutamine stress echocardiography: Appropriateness of indications and protocol compliance. A single-centre report].

    Annales de cardiologie et d'angeiologie·2026
    Same author

    Aortic thrombosis and concomitant acute pulmonary embolism complicating SARS COV2 infection.

    Journal de medecine vasculaire·2022
    Same author

    Analysis and gonadal localization of Speedy A mRNA transcript, a novel gene associated with early germline cells in the scallop, Argopecten purpuratus.

    Animal reproduction science·2021
    Same author

    Acute Myocarditis after COVID-19 vaccination: A case report.

    La Revue de medecine interne·2021
    Same author

    [Particularities of African descent patient's electrocardiogram].

    Annales de cardiologie et d'angeiologie·2020
    Same author

    Evaluation of the Beckman Coulter DxC 700 AU chemistry analyzer.

    Practical laboratory medicine·2019
    Same journal

    Post-weaning social isolation increases reward-seeking behavior in mice.

    Physiology & behavior·2026
    Same journal

    DHEA model of PCOS selectively alters reproductive but not metabolic or behavioral phenotypes in female Long-Evans rats.

    Physiology & behavior·2026
    Same journal

    Importance of Apparatus Scaling in Novel Object Recognition for Juvenile and Adult Rats.

    Physiology & behavior·2026
    Same journal

    Chronic activity-based anorexia alters food intake microstructure in a time-dependent manner in female rats.

    Physiology & behavior·2026
    Same journal

    Apelin receptor antagonist (ML221) facilitates memory reconsolidation in novel object recognition task.

    Physiology & behavior·2026
    Same journal

    Are humans adapted to the world they have developed?

    Physiology & behavior·2026
    See all related articles

    Electrical stimulation of the ventromedial tegmentum (VT) has dual effects on escape responses. These effects, suppressant or facilitating, depend on stimulation location and intensity, and correlate with rewarding or aversive properties.

    Area of Science:

    • Neuroscience
    • Behavioral Neuroscience
    • Neurophysiology

    Background:

    • The ventromedial tegmentum (VT) is implicated in various behavioral processes.
    • Electrical brain stimulation is a tool to probe neural circuit functions.
    • Escape responding is a fundamental defensive behavior.

    Purpose of the Study:

    • To investigate the dual effects (suppressant and facilitating) of ventromedial tegmentum (VT) stimulation on escape responses.
    • To determine the relationship between VT stimulation's effects on escape behavior and its rewarding/aversive properties.
    • To explore how stimulation parameters influence VT's impact on escape behavior.

    Main Methods:

    • Electrical stimulation was applied to the ventromedial tegmentum (VT) in rodents.

    Related Experiment Videos

  • Escape responses were induced by stimulating the medial hypothalamus (MH) or dorsal central gray matter (CG).
  • Suppressive and facilitative effects of VT stimulation on escape behavior were quantified.
  • Rewarding and aversive properties of VT stimulation were assessed, including self-stimulation rates.

    • Main Results:

    • VT stimulation exhibited both suppressant and facilitating effects on MH- or CG-induced escape responses.
    • The magnitude and nature of VT's effect depended on stimulation site location and intensity.
    • VT stimulation's impact on escape behavior correlated negatively with its self-stimulation rate, suggesting a link to rewarding/aversive properties.

    Conclusions:

    • Ventromedial tegmentum (VT) stimulation modulates escape behavior through both suppression and facilitation.
    • The observed effects are influenced by stimulation parameters and are intrinsically linked to the rewarding and aversive characteristics of VT stimulation.
    • These findings contribute to understanding the neural mechanisms underlying defensive behaviors and reward processing.