Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

NeuroFlare: An mm<sup>3</sup>-Scale Wireless Neural Interface Device with Simultaneous Neural Recording and Optical Stimulation.

IEEE journal of solid-state circuits·2026
Same author

Low-power analog and mixed-signal circuit techniques for next-generation miniature implantable neural interface systems.

Biomedical engineering letters·2026
Same author

A Wireless Miniature Injectable Device With Memory-Assisted Backscatter for Multimodal Animal Physiological Monitoring.

IEEE transactions on bio-medical engineering·2024
Same author

A Wirelessly Powered Scattered Neural Recording Wearable System.

IEEE transactions on biomedical circuits and systems·2024
Same author

A Wireless Multimodal Physiological Monitoring ASIC for Animal Health Monitoring Injectable Devices.

IEEE transactions on biomedical circuits and systems·2024
Same author

A highly stable electrode with low electrode-skin impedance for wearable brain-computer interface.

Biosensors & bioelectronics·2022

Related Experiment Video

Updated: Jun 7, 2025

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
06:36

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Published on: September 1, 2022

3.7K

An Energy-Efficient and Artifact-Resilient ASIC for Simultaneous Neural Recording and Optogenetic Stimulation.

Linran Zhao, Yan Gong, Raymond G Stephany

    IEEE Transactions on Biomedical Circuits and Systems
    |November 11, 2024
    PubMed
    Summary

    This study introduces a novel integrated circuit for simultaneous neural recording and optogenetic stimulation. The device efficiently drives stimulation and digitizes neural signals, overcoming artifact challenges for improved neuroscience research.

    More Related Videos

    Author Spotlight: Unraveling Neural Communication and Circuit Interactions in Health and Disease
    06:55

    Author Spotlight: Unraveling Neural Communication and Circuit Interactions in Health and Disease

    Published on: November 21, 2024

    677
    A Method for High Fidelity Optogenetic Control of Individual Pyramidal Neurons In vivo
    13:44

    A Method for High Fidelity Optogenetic Control of Individual Pyramidal Neurons In vivo

    Published on: September 2, 2013

    19.0K

    Related Experiment Videos

    Last Updated: Jun 7, 2025

    Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
    06:36

    Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

    Published on: September 1, 2022

    3.7K
    Author Spotlight: Unraveling Neural Communication and Circuit Interactions in Health and Disease
    06:55

    Author Spotlight: Unraveling Neural Communication and Circuit Interactions in Health and Disease

    Published on: November 21, 2024

    677
    A Method for High Fidelity Optogenetic Control of Individual Pyramidal Neurons In vivo
    13:44

    A Method for High Fidelity Optogenetic Control of Individual Pyramidal Neurons In vivo

    Published on: September 2, 2013

    19.0K

    Area of Science:

    • Neuroscience
    • Electrical Engineering
    • Biomedical Engineering

    Background:

    • Optogenetic stimulation and neural recording are crucial tools in neuroscience research.
    • Existing systems face challenges with power delivery for stimulation and artifact handling during recording.
    • Integrated circuits offer a path to miniaturization and improved performance for neural interfaces.

    Purpose of the Study:

    • To develop an Application-Specific Integrated Circuit (ASIC) for simultaneous neural recording and optogenetic stimulation.
    • To design an efficient stimulation driver and a robust recording frontend to overcome existing limitations.
    • To validate the ASIC's functionality for in vivo neural applications.

    Main Methods:

    • Fabrication of an ASIC using a CMOS 180 nm process.
    • Implementation of a voltage-boosting switched-capacitor-based stimulation (VB-SCS) driver capable of 8 mA current pulses.
    • Integration of a direct digitizing recording frontend with a delta-sigma (ΔΣ) analog-to-digital converter (ADC) featuring a Gm-C integrator and noise-shaping (NS) SAR quantizer.

    Main Results:

    • The VB-SCS driver reduces the required supply voltage by half, aiding wireless power reception.
    • The ΔΣ ADC-based frontend tolerates stimulation artifacts up to 300 mVPP.
    • The recording frontend achieved 11.4 bits effective number of bits (ENOB) with a power consumption of 10.8 μW.
    • Successful in vivo verification of the ASIC's functionality when assembled into a headstage.

    Conclusions:

    • The developed ASIC enables simultaneous neural recording and optogenetic stimulation with enhanced efficiency and artifact resilience.
    • The integrated VB-SCS driver and direct digitizing frontend represent a significant advancement for neural interface technology.
    • This ASIC platform holds promise for future neuroscience research requiring precise neural control and monitoring.