Association Between Atopic Dermatitis and Meniere's Disease: Nationwide Cohort Study
Cha Dong Yeo1,2, Haeng-Jin Lee2,3, Jong Seung Kim1,2,4
1Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Jeonbuk National University, Jeonju, Republic of Korea.
The Laryngoscope
|November 12, 2024
Summary
Individuals with atopic dermatitis (AD) have a 1.44 times higher risk of developing Meniere's disease. Risk factors include older age, female sex, and allergic comorbidities.
Area of Science:
- Dermatology and Otolaryngology
- Epidemiology
- Allergy and Immunology
Background:
- Atopic dermatitis (AD) is a chronic inflammatory skin condition often associated with other allergic diseases.
- The relationship between atopic dermatitis and Meniere's disease remains under-investigated.
Purpose of the Study:
- To investigate the potential correlation between atopic dermatitis and the incidence of Meniere's disease.
- To identify risk factors associated with developing Meniere's disease in patients with AD.
Main Methods:
- Utilized a nationwide population-based database (National Health Insurance Service-National Sample Cohort).
- Included a cohort of 1 million individuals, with an atopic dermatitis (AD) group and a propensity score-matched non-AD control group.
- Employed long-term follow-up and hazard ratio analysis.
Main Results:
- The overall hazard ratio for Meniere's disease in the AD group was 1.44 (95% CI: 1.31-1.6).
- Subgroup analyses revealed increased risk in older age groups (≥60 years: HR 8.21) and females.
- Comorbidities such as allergic rhinitis (HR 1.18), allergic contact dermatitis (HR 1.32), and allergic conjunctivitis (HR 1.54) significantly increased Meniere's disease risk.
Conclusions:
- Atopic dermatitis is associated with a significantly higher prevalence of Meniere's disease.
- Older age, female sex, and specific allergic comorbidities are identified as key risk factors for developing Meniere's disease in AD patients.
