Association between triglyceride glucose index and asthma exacerbation: A population-based study
Zhou Jin1, Wen Sun1, Junjun Huang1
1Department of Respiratory and Critical Care Medicine, Peking University First Hospital, Beijing, China.
Heart & Lung : the Journal of Critical Care
|November 12, 2024
Summary
The triglyceride-glucose (TyG) index shows a nonlinear positive association with asthma exacerbations. This suggests TyG may help manage asthma, especially with gender-specific strategies.
Area of Science:
- Metabolic health and respiratory disease research.
- Clinical epidemiology and biomarker analysis.
Background:
- Metabolic dysfunction is linked to respiratory illnesses.
- The triglyceride-glucose (TyG) index is a key metabolic dysfunction indicator.
Purpose of the Study:
- To investigate the relationship between the TyG index and asthma exacerbations.
- To identify potential subgroup variations in this association.
Main Methods:
- Analysis of 2009-2018 National Health and Nutrition Examination Survey (NHANES) data.
- Utilized multifactorial logistic regression, subgroup analysis, and smoothed curve fitting.
- Examined threshold effects for a comprehensive relationship assessment.
Main Results:
- A nonlinear positive association was observed between TyG index and asthma exacerbation risk.
- Each unit increase in TyG correlated with a 25% rise in asthma exacerbation risk (OR:1.25).
- Significant associations found in females, specific age groups (20-59), and varying BMI categories; a U-shaped relationship noted in males.
Conclusions:
- The TyG index demonstrates a nonlinear positive association with asthma exacerbation.
- TyG index holds potential clinical value for asthma management.
- Highlights the necessity for gender-specific risk management approaches in asthma care.
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