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Polyradiculitis as a Neurological Complication Associated with Adagrasib: A Case Report.
Kristofoor E Leeuwenberg1, Rob Ter Heine2, Johanna M M Gijtenbeek1
1Department of Neurology, Radboud Research Institute for Medical Innovation, Donders Institute for Brain, Cognition and Behavior, Nijmegen, The Netherlands.
Case Reports in Oncology
|November 13, 2024
Summary
Adagrasib, a new cancer drug, may cause polyradiculitis, a rare neurological side effect. Early recognition and dose adjustment can manage this complication while maintaining tumor response.
Area of Science:
- Oncology
- Neurology
- Pharmacology
Background:
- Adagrasib is a targeted therapy for KRAS G12C-mutated cancers.
- Neurological adverse events associated with adagrasib are reportedly uncommon.
Observation:
- A 70-year-old woman developed polyradiculitis during adagrasib treatment.
- Symptoms resolved with prednisone and adagrasib dose modification.
Findings:
- This case represents the first reported instance of adagrasib-induced polyradiculitis.
- Adagrasib dose reduction maintained therapeutic serum concentrations and anti-tumor efficacy.
Implications:
- Clinicians should consider polyradiculitis as a potential adverse event of adagrasib.
- Awareness of this side effect is crucial for managing patients on adagrasib therapy.
