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Transformative applications of oculomics-based AI approaches in the management of systemic diseases: A systematic
Zhongwen Li1, Shiqi Yin2, Shihong Wang2
1Ningbo Key Laboratory of Medical Research on Blinding Eye Diseases, Ningbo Eye Institute, Ningbo Eye Hospital, Wenzhou Medical University, Ningbo 315040, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.
Insights
Artificial intelligence (AI) using eye imaging (oculomics) shows promise for managing systemic diseases. This cost-effective, non-invasive approach aids early detection and staging, improving patient outcomes.
Area of Science:
- Ophthalmology
- Artificial Intelligence
- Medical Diagnostics
Background:
- Systemic diseases present significant global health challenges with high mortality rates.
- Current diagnostic methods are often complex, expensive, and invasive, hindering timely detection.
- There is a need for cost-effective, non-invasive methods for systemic disease management.
Purpose of the Study:
- To systematically review the use of artificial intelligence (AI) algorithms in managing systemic diseases.
- To analyze the potential of oculomics (ophthalmic features) for disease management.
- To assess AI's accuracy and feasibility using non-invasive ophthalmic imaging.
Main Methods:
- Systematic review of studies applying AI to ophthalmic data for systemic disease management.
- Analysis of oculomics-based AI algorithms for prediction and staging.
- Evaluation of study quality and potential biases.
Main Results:
- AI demonstrates promising accuracy in predicting systemic diseases using oculomics.
- AI shows potential for disease staging, though caution is needed regarding low-quality studies.
- Oculomics-based AI systems are cost-effective, safe, and well-accepted by patients and clinicians.
Conclusions:
- Oculomics-based AI holds significant potential for revolutionizing systemic disease management.
- AI offers a viable, non-invasive strategy for early detection, diagnosis, and monitoring.
- Further high-quality research is essential to fully realize the capabilities of AI in oculomics.
Background:
Systemic diseases, such as cardiovascular and cerebrovascular conditions, pose significant global health challenges due to their high mortality rates. Early identification and intervention in systemic diseases can substantially enhance their prognosis. However, diagnosing systemic diseases often necessitates complex, expensive, and invasive tests, posing challenges in their timely detection. Therefore, simple, cost-effective, and non-invasive methods for the management (such as screening, diagnosis, and monitoring) of systemic diseases are needed to reduce associated comorbidities and mortality rates.
Aim Of The Review:
This systematic review examines the application of artificial intelligence (AI) algorithms in managing systemic diseases by analyzing ophthalmic features (oculomics) obtained from convenient, affordable, and non-invasive ophthalmic imaging.
Key Scientific Concepts Of Review:
Our analysis demonstrates the promising accuracy of AI in predicting systemic diseases. Subgroup analysis reveals promising capabilities of oculomics-based AI for disease staging, while caution is warranted due to the possible overestimation of AI capabilities in low-quality studies. These systems are cost-effective and safe, with high rates of acceptance among patients and clinicians. This review underscores the potential of oculomics-based AI approaches in revolutionizing the management of systemic diseases.
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