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Updated: Jul 19, 2026

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
Published on: September 13, 2019
[Of muscle and bone: Diagnostic challenge of an uncommonly located rhabdomyosarcoma]
Simon Phélinas1, Marie Karanian2, Nadège Corradini3
1Institut de pathologie multisite, hospices civils de Lyon, Lyon, France.
Abstract:
Rhabdomyosarcomas form a heterogeneous group of malignant soft tissue tumors characterized by immature striated muscle differentiation. Epithelioid and spindle cell rhabdomyosarcoma is a recently described entity, mainly localized intraosseously and predominantly found in young patients. Its late diagnosis and high aggressiveness confer a grim prognosis to this tumor, highlighting the importance of early recognition and appropriate management. We present herein the clinical, histopathological, immunohistochemical, and molecular aspects of this entity through a case of misleading presentation.
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