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Updated: Jun 7, 2025

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
Published on: February 12, 2022
Management of Localized and Locally Advanced Anal Cancer
Stevie-Jay Stapler1, Drew J Gunnells2, Robert H Hollis3
1Division of Gastrointestinal Surgery, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: https://twitter.com/colons_costumes.
Abstract:
The initial evaluation and workup of anal canal cancer and perianal cancer is the same, but treatment strategies differ based on stage and location of disease. Chemoradiation remains the cornerstone of treatment for anal canal squamous cell carcinoma (SCC), while surgery is typically reserved for persistent or recurrent disease. Perianal SCC can be treated with local excision for early stage disease (T1N0, select T2N0) or chemoradiation for later stages. Despite advancements in treatment strategies, excellent tumor response to neoadjuvant therapy, and surgical technique, additional work is needed to continue to improve outcomes and mitigate treatment-related toxicities.
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